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Randomization was stratified by response to ALIMTA in combination with cisplatin induction therapy (CR or PR versus SD), disease stage (IIIb versus IV), and ECOG PS (0 versus 1)
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Silencing P65 or EAAT3 increases ROS levels and reduces GSH synthesis, but these changes alone are insufficient to trigger significant cell death due to the robust ferroptosis-resistance mechanisms in cancer cells, including the xCT-GSH-GPX4 system and other protective pathways
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